Particle breakability assessment using an Aero S disperser

نویسندگان

چکیده

Milling is widely used in various industries to tailor the particle size distribution for desired attributes. The ability predict milling behaviour by testing breakability of a small quantity material great interest. In this paper, available aerodynamic dispersion method, i.e. Aero S disperser Malvern Mastersizer 3000 has been evaluated purpose. This device commonly fine and cohesive powders, as particles are accelerated impacted at bend, but here its use assessing explored. fluid flow field modelled using one-way coupled Computational Fluid Dynamics approach, concentration low, following which impact velocity calculated Lagrangian tracking analysis breakage. Experimental work on carried out aspirin, paracetamol, sucrose ?–lactose monohydrate particles. relative shift specific surface area determined together with physical properties, they calculate index. A good agreement obtained single Scirocco disperser, indicating could also be inferred from method.

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ژورنال

عنوان ژورنال: International Journal of Pharmaceutics

سال: 2021

ISSN: ['0378-5173', '1873-3476']

DOI: https://doi.org/10.1016/j.ijpharm.2021.120365